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KMID : 0370220190630040247
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Yakhak Hoeji
2019 Volume.63 No. 4 p.247 ~ p.250
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Synthesis and Evaluation of Sitagliptin Analogs
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Vo Duy Viet
Park Hae-Il
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Abstract
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Three sitagliptin analogs with propan-2-amine backbone carbon chain and 1,2,3-triazole were synthesized andevaluated for their DPP-4 inhibitory activity against recombinant human DPP-4 enzyme. All the analogs exhibitedmoderate to strong inhibitory activities.
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KEYWORD
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Sitagliptin, DPP-4 enzyme, antidiabetic agent, fragment structure, backbone carbon chain
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